Prof. Steven A. Soper List of publications (2002-2009)

Okagbare, Paul I.; and Soper, Steven A. High throughput single molecule detection for monitoring biochemical reactions. Analyst, 2009, 134, 97-106.

Osiri, J.K.; Shadpour, H.; Park, S.; Snowden, B.C.; Chen, Z.; and Soper, S.A. Generating High Peak Capacity 2-Dimensional Maps of Complex Proteomes using Poly (methylmethacrylate) Microchip Electrophoresis. Electrophoresis 2008, 29, 4984-4992.

Balamurugan, Subramanian; Obubuafo, Anne; McCarley, Robin L; Soper, Steven A.; Spivak, David A. Effect of linker structure on surface density of aptamer monolayers and their corresponding protein binding efficiency. Anal. Chem., 2008, 80(24), 9630-9634.

Bolivar Jowell G.; Soper, Steven A.; McCarley, Robin L. Nitroavidin as a ligand for the surface capture and release of biotinylated proteins. Anal. Chem., 2008, 80(23), 9336-9342.

Mei, Qian; Xia, Zheng; Soper, Steven A; Fan, Z. Hugh. Fabrication of microfluidic reactors and mixing studies for luciferase detection. Anal. Chem., 2008, 80(15), 6045-6050.

Sinville, Rondedrick; Coyne, Jennifer; Meagher, Robert J.; Cheng, Yu-Wei; Barany, Francis; Barron, Annelise; Soper, Steven A. Ligase detection reaction for the analysis of point mutations using free-solution conjugate electrophoresis in a polymer microfluidic device. Electrophoresis 2008, 29, 4751-4760.

Obubuafo, Anne; Balamurugan, Subramanian; Shadpour, Hamed; Spivak David; McCarley, Robin L; Soper, Steven A. Poly(methyl methacrylate) microchip affinity capillary gel electrophoresis of aptamer-protein complexes for the analysis of thrombin in plasma. Electrophoresis 2008, August; 29(16), 3436-3445.

Sibel, Erdem, S.; Nesterova, Irina V.; Soper, Steven A.; Hammer, Robert P. Solid-phase synthesis of asymmetrically substituted “AB3-Type” phythalocyanines. Journal of Organic Chemistry 2008, 73(13), 5003-5007.

Lee, Jeonghoon; Musyimi, Harrison K.; Soper, Steven A.; Murray, Kermit K. Development of an automated digestion and droplet deposition microfluidic chip for MALDI-TOF MS. Journal of the American Society for Mass Spectrometry, 2008, 19, 964-972.

Balamurugan, Subramanian; Obubuafo, Anne; Soper, Steven A.; Spivak, David A. Surface immobilization methods for aptamer diagnostic applications. Analytical and Bioanalytical Chemistry (2008), 390(4), 1009-1021.

Park, D. S.-W.; Hupert, M. L.; Witek, M. A.; You, B. H.; Datta, P.; Guy, J.; Lee, J.-B.; Soper, S. A.; Nikitopoulos, D. E.; Murphy, M. C. A titer plate-based polymer microfluidic platform for high throughput nucleic acid purification. Biomedical Microdevices (2008), 10(1), 21-33

Nesterova, Irina V.; Verdree, Vera T.; Pakhomov, Serhii; Strickler, Karen L.; Allen, Michael W.; Hammer, Robert P.; Soper, Steven A. Metallo-Phthalocyanine Near-IR Fluorophores: Oligonucleotide Conjugates and Their Applications in PCR Assays. Bioconjugate Chemistry (2007), 18(6), 2159-2168.

Chen, Guofang; McCandless, Gregory T.; McCarley, Robin L.; Soper, Steven A. Integration of large-area polymer nanopillar arrays into microfluidic devices using in situ polymerization cast molding. Lab on a Chip (2007), 7(11), 1424-1427.

Xu, Feng; Datta, Proyag; Wang, Hong; Gurung, Sitanshu; Hashimoto, Masahiko; Wei, Suying; Goettert, Jost; McCarley, Robin L.; Soper, Steven A. Polymer microfluidic chips with integrated waveguides for reading microarrays. Analytical Chemistry (Washington, DC, United States) (2007), 79(23), 9007-9013.

Chen, Guofang; Soper, Steven A.; McCarley, Robin L. Free-standing, erect ultrahigh-aspect-ratio polymer nano pillar and nano tube ensembles. Langmuir (2007), 23(23), 11777-11781.

Verdree, Vera T.; Pakhomov, Serhii; Su, Guifa; Allen, Michael W.; Countryman, Amber C.; Hammer, Robert P.; Soper, Steven A. Water Soluble Metallo-Phthalocyanines: The Role of the Functional Groups on the Spectral and Photophysical Properties. Journal of Fluorescence (2007), 17(5), 547-563.

Hashimoto, Masahiko; Barany, Francis; Xu, Feng; Soper, Steven A. Serial processing of biological reactions using flow-through microfluidic devices: Coupled PCR/LDR for the detection of low-abundant DNA point mutations. Analyst (Cambridge, United Kingdom) (2007), 132(9), 913-921.

Sinville, Rondedrick; Soper, Steven A. High resolution DNA separations using microchip electrophoresis. Journal of Separation Science (2007), 30(11), 1714-1728.

Chen, Guofang; McCarley, Robin L.; Soper, Steven A.; Situma, Catherine; Bolivar, Jowell G. Functional Template-Derived Poly(methyl methacrylate) Nanopillars for Solid-Phase Biological Reactions. Chemistry of Materials (2007), 19(16), 3855-3857.

Zhu, Li; Soper, Steven A.. Ultra sensitive time-resolved near-IR fluorescence for multiplexed bioanalysis. Chemical Analysis (Hoboken, NJ, United States) (2007), 172(New Frontiers in Ultrasensitive Bioanalysis), 141-168.

Llopis, Shawn L.; Osiri, John; Soper, Steven A. Surface modification of poly(methyl methacrylate) microfluidic devices for high-resolution separations of single-stranded DNA. Electrophoresis (2007), 28(6), 984-993.

Hupert, Mateusz L.; Guy, W. Jason; Llopis, Shawn D.; Shadpour, Hamed; Rani, Sudheer; Nikitopoulos, Dimitris E.; Soper, Steven A.. Evaluation of micromilled metal mold masters for the replication of microchip electrophoresis devices. Microfluidics and Nanofluidics (2007), 3(1), 1-11.

Sibrian-Vazquez, M., J. Ortiz, I.V. Nesterova, F. Fernandez-Lazaro, A. Sastre-Santos, S.A. Soper, and M.G.H. Vicente, Synthesis and properties of cell-targeted zn(ii)-phthalocyanine-peptide conjugates. Bioconjugate Chemistry, 2007. 18(2): p. 410-420.

Situma, C., A.J. Moehring, M.A.F. Noor, and S.A. Soper, Immobilized molecular beacons: A new strategy using uv-activated poly(methyl methacrylate) surfaces to provide large fluorescence sensitivities for reporting on molecular association events. Analytical Biochemistry, 2007. 363(1): p. 35-45.

Shadpour, H., M.L. Hupert, D. Patterson, C. Liu, M. Galloway, W. Stryjewski, J. Goettert, and S.A. Soper, Multichannel microchip electrophoresis device fabricated in polycarbonate with an integrated contact conductivity sensor array. Analytical Chemistry, 2007. 79(3): p. 870-878.

Yang, R., S.A. Soper, and W. Wang, Microfabrication of pre-aligned fiber bundle couplers using ultraviolet lithography of su-8. Sensors and Actuators, A: Physical, 2006. A127(1): p. 123-130.

Witek, M.A., S.D. Llopis, A. Wheatley, R.L. McCarley, and S.A. Soper, Purification and preconcentration of genomic DNA from whole cell lysates using photoactivated polycarbonate (ppc) microfluidic chips. Nucleic Acids Research, 2006. 34(10): p. e74/1-e74/9.

Wang, H., J. Chen, L. Zhu, H. Shadpour, M.L. Hupert, and S.A. Soper, Continuous flow thermal cycler microchip for DNA cycle sequencing. Analytical Chemistry, 2006. 78(17): p. 6223-6231.

Soper, S.A., K. Brown, A. Ellington, B. Frazier, G. Garcia-Manero, V. Gau, S.I. Gutman, D.F. Hayes, B. Korte, J.L. Landers, D. Larson, F. Ligler, A. Majumdar, M. Mascini, D. Nolte, Z. Rosenzweig, J. Wang, and D. Wilson, Point-of-care biosensor systems for cancer diagnostics/prognostics. Biosensors & Bioelectronics, 2006. 21(10): p. 1932-1942.

Situma, C., M. Hashimoto, and S.A. Soper, Merging microfluidics with microarray-based bioassays. Biomolecular Engineering, 2006. 23(5): p. 213-231.

Shadpour, H. and S.A. Soper, Two-dimensional electrophoretic separation of proteins using poly(methyl methacrylate) microchips. Analytical Chemistry, 2006. 78(11): p. 3519-3527.

Shadpour, H., H. Musyimi, J. Chen, and S.A. Soper, Physiochemical properties of various polymer substrates and their effects on microchip electrophoresis performance. Journal of Chromatography, A, 2006. 1111(2): p. 238-251.

Lee, D.E., S.A. Soper, and W. Wang, Fabrication and test of an electrochemical microactuator. Proceedings of SPIE-The International Society for Optical Engineering, 2006. 6112(Microfluidics, BioMEMS, and Medical Microsystems IV): p. 61120N/1-61120N/10.

Kong, Y., H. Chen, Y. Wang, and S.A. Soper, Fabrication of a gold microelectrode for amperometric detection on a polycarbonate electrophoresis chip by photodirected electroless plating. Electrophoresis, 2006. 27(14): p. 2940-2950.

Hupert, M.L., W.J. Guy, S.D. Llopis, C. Situma, S. Rani, D.E. Nikitopoulos, and S.A. Soper, High-precision micromilling for low-cost fabrication of metal mold masters. Proceedings of SPIE-The International Society for Optical Engineering, 2006. 6112(Microfluidics, BioMEMS, and Medical Microsystems IV): p. 61120B/1-61120B/12.

Hashimoto, M., F. Barany, and A. Soper Steven, Polymerase chain reaction/ligase detection reaction/hybridization assays using flow-through microfluidic devices for the detection of low-abundant DNA point mutations. Biosens Bioelectron FIELD Full Journal Title:Biosensors & bioelectronics, 2006. 21(10): p. 1915-23.

Hashimoto, M., F. Barany, and S.A. Soper, Polymerase chain reaction/ligase detection reaction/hybridization assays using flow-through microfluidic devices for the detection of low-abundant DNA point mutations. Biosensors & Bioelectronics, 2006. 21(10): p. 1915-1923.

Dovichi, N.J. and S.A. Soper, Cost-benefit analysis of rfa. Science (Washington, DC, United States), 2006. 314(5806): p. 1682

Datta, P., F. Xu, S. Gurung, S.A. Soper, and J. Goettert, Polymeric waveguides for orthogonal near surface fluorescent excitation. Proceedings of SPIE-The International Society for Optical Engineering, 2006. 6112(Microfluidics, BioMEMS, and Medical Microsystems IV): p. 611208/1-611208/8.

Balamurugan, S., A. Obubuafo, S.A. Soper, R.L. McCarley, and D.A. Spivak, Designing highly specific biosensing surfaces using aptamer monolayers on gold. Langmuir, 2006. 22(14): p. 6446-6453.

Yang, R., W. Wang, and S.A. Soper, Out-of-plane microlens array fabricated using ultraviolet lithography. Applied Physics Letters, 2005. 86(16): p. 161110/1-161110/3.

Yang, R., S.A. Soper, and W. Wang, Microfabrication of an integrated su-8 waveguide with an embedded focusing lens for application in single-molecule detection. Proceedings of SPIE-The International Society for Optical Engineering, 2005. 5718(Microfluidics, BioMEMS, and Medical Microsystems III): p. 54-59.

Yang, R., S.A. Soper, and W. Wang, Fabrication of out-of-plane refractive concave and convex microlens arrays. Proceedings of SPIE-The International Society for Optical Engineering, 2005. 5717(MEMS/MOEMS Components and Their Applications II): p. 134-141.

Wei, S., B. Vaidya, A.B. Patel, S.A. Soper, and R.L. McCarley, Photochemically patterned poly(methyl methacrylate) surfaces used in the fabrication of microanalytical devices. Journal of Physical Chemistry B, 2005. 109(35): p. 16988-16996.

Soper, S.A., M. Hashimoto, C. Situma, M.C. Murphy, R.L. McCarley, Y.-W. Cheng, and F. Barany, Fabrication of DNA microarrays onto polymer substrates using uv modification protocols with integration into microfluidic platforms for the sensing of low-abundant DNA point mutations. Methods (San Diego, CA, United States), 2005. 37(1): p. 103-113.

Situma, C., Y. Wang, M. Hupert, F. Barany, R.L. McCarley, and S.A. Soper, Fabrication of DNA microarrays onto poly(methyl methacrylate) with ultraviolet patterning and microfluidics for the detection of low-abundant point mutations. Analytical Biochemistry, 2005. 340(1): p. 123-135.

Sen, S., P. Fawson, G. Cherrington, K. Douglas, N. Friedman, R. Maljanian, K. Fitzner, P. Tang, S. Soper, and S. Wood, Patient satisfaction measurement in the disease management industry. Dis Manag FIELD Full Journal Title:Disease management : DM, 2005. 8(5): p. 288-300.

Musyimi, H.K., J. Guy, D.A. Narcisse, S.A. Soper, and K.K. Murray, Direct coupling of polymer-based microchip electrophoresis to online maldi-ms using a rotating ball inlet. Electrophoresis, 2005. 26(24): p. 4703-4710.

McCarley, R.L., B. Vaidya, S. Wei, A.F. Smith, A.B. Patel, J. Feng, M.C. Murphy, and S.A. Soper, Resist-free patterning of surface architectures in polymer-based microanalytical devices. Journal of the American Chemical Society, 2005. 127(3): p. 842-843.

Hashimoto, M., M.L. Hupert, M.C. Murphy, S.A. Soper, Y.-W. Cheng, and F. Barany, Ligase detection reaction/hybridization assays using three-dimensional microfluidic networks for the detection of low-abundant DNA point mutations. Analytical Chemistry, 2005. 77(10): p. 3243-3255.

Chen, J., M. Wabuyele, H. Chen, D. Patterson, M. Hupert, H. Shadpour, D. Nikitopoulos, and S.A. Soper, Electrokinetically synchronized polymerase chain reaction microchip fabricated in polycarbonate. Analytical Chemistry, 2005. 77(2): p. 658-666.

Zhu, L., W.J. Stryjewski, and S.A. Soper, Multiplexed fluorescence detection in microfabricated devices with both time-resolved and spectral-discrimination capabilities using near-infrared fluorescence. Analytical Biochemistry, 2004. 330(2): p. 206-218.

Witek, M.A., S. Wei, B. Vaidya, A.A. Adams, L. Zhu, W. Stryjewski, R.L. McCarley, and S.A. Soper, Cell transport via electromigration in polymer-based microfluidic devices. Lab on a Chip, 2004. 4(5): p. 464-472.

Trottier, C., M. Davies, H. Dautet, M. Wabuyele, S.A. Soper, A.N. Kapanidis, T. Lacoste, and S. Weiss, Single photon-counting technology: For single-molecule detection applications in biotechnology. PharmaGenomics, 2004. 4(2): p. 24-26, 28-30, 32-34.

Thomas, G., R. Sinville, S. Sutton, H. Farquar, R.P. Hammer, S.A. Soper, Y.-W. Cheng, and F. Barany, Capillary and microelectrophoretic separations of ligase detection reaction products produced from low-abundant point mutations in genomic DNA. Electrophoresis, 2004. 25(10-11): p. 1668-1677.

Musyimi, H.K., D.A. Narcisse, X. Zhang, W. Stryjewski, S.A. Soper, and K.K. Murray, Online ce-maldi-tof ms using a rotating ball interface. Analytical Chemistry, 2004. 76(19): p. 5968-5973.

McCarley, R.L., S.A. Soper, M.C. Murphy, S. Wei, A.F. Smith, B. Vaidya, and J. Feng, Patterning of surface-capture architectures in polymer-based microanalytical devices. Special Publication - Royal Society of Chemistry, 2004. 297(Micro Total Analysis Systems 2004, Volume 2): p. 130-132.

Maha, A., D.O. Barrett, D.E. Nikitopoulos, S.A. Soper, and M.C. Murphy, Simulation and design of micromixers for microfluidic devices. Proceedings of SPIE-The International Society for Optical Engineering, 2004. 5345(Microfluidics, BioMEMs, and Medical Microsystems II): p. 183-193.

Llopis, S.D., W. Stryjewski, and S.A. Soper, Near-infrared time-resolved fluorescence lifetime determinations in poly(methylmethacrylate) microchip electrophoresis devices. Electrophoresis, 2004. 25(21-22): p. 3810-3819.

Hashimoto, M., P.-C. Chen, M.W. Mitchell, D.E. Nikitopoulos, S.A. Soper, and M.C. Murphy, Rapid pcr in a continuous flow device. Lab on a Chip, 2004. 4(6): p. 638-645.

Barrett, D.O., A. Maha, Y. Wang, S.A. Soper, D.E. Nikitopoulos, and M.C. Murphy, Design of a microfabricated device for ligase detection reaction (ldr). Proceedings of SPIE-The International Society for Optical Engineering, 2004. 5345(Microfluidics, BioMEMs, and Medical Microsystems II): p. 78-88.

Adams, A.A., J. Feng, M.C. Murphy, and S.A. Soper, Low abundant biomarker screening in poly(methylmethacrylate) high aspect ratio microstructures using immunoaffinity-based molecular recognition. Special Publication - Royal Society of Chemistry, 2004. 296(Micro Total Analysis Systems 2004, Volume 1): p. 132-134.

Zhu, L., W. Stryjewski, S. Lassiter, and S.A. Soper, Fluorescence multiplexing with time-resolved and spectral discrimination using a near-ir detector. Analytical Chemistry, 2003. 75(10): p. 2280-2291.

Xu, Y., B. Vaidya, A.B. Patel, S.M. Ford, R.L. McCarley, and S.A. Soper, Solid-phase reversible immobilization in microfluidic chips for the purification of dye-labeled DNA sequencing fragments. Analytical Chemistry, 2003. 75(13): p. 2975-2984.

Wang, Y., B. Vaidya, H.D. Farquar, W. Stryjewski, R.P. Hammer, R.L. McCarley, S.A. Soper, Y.-W. Cheng, and F. Barany, Microarrays assembled in microfluidic chips fabricated from poly(methyl methacrylate) for the detection of low-abundant DNA mutations. Analytical Chemistry, 2003. 75(5): p. 1130-1140.

Wabuyele, M.B., H. Farquar, W.J. Stryjewski, R.P. Hammer, S.A. Soper, Y.-W. Cheng, and F. Barany, Detection of low abundant mutations in DNA using single-molecule fret and ligase detection reactions. Proceedings of SPIE-The International Society for Optical Engineering, 2003. 4962 (Manipulation and Analysis of Biomolecules, Cells, and Tissues): p. 58-69.

Wabuyele, M.B., H. Farquar, W. Stryjewski, R.P. Hammer, S.A. Soper, Y.-W. Cheng, and F. Barany, Approaching real-time molecular diagnostics: Single-pair fluorescence resonance energy transfer (spfret) detection for the analysis of low abundant point mutations in k-ras oncogenes. Journal of the American Chemical Society, 2003. 125(23): p. 6937-6945.

Soper, S.A., C.V. Owens, S.J. Lassiter, Y. Xu, and E. Waddell, DNA sequencing using fluorescence detection. Biomedical Photonics Handbook, 2003: p. 53/1-53/48, 2 plates.

Soper, S.A., C. Owens, S. Lassiter, Y. Xu, and E. Waddell, DNA sequencing using fluorescence detection. Topics in Fluorescence Spectroscopy, 2003. 7(DNA Technology): p. 1-68.

McCarley, R.L., S.A. Soper, B. Vaidya, A.C. Henry, A.F. Smith, S. Wei, M. Galloway, and Y. Wang, Augmenting the capabilities of polymeric microanalytical devices. Polymer Preprints (American Chemical Society, Division of Polymer Chemistry), 2003. 44(2): p. 549.

Vaidya, B., S.A. Soper, and R.L. McCarley, Surface modification and characterization of microfabricated poly(carbonate) devices: Manipulation of electroosmotic flow. Analyst (Cambridge, United Kingdom), 2002. 127(10): p. 1289-1292.

Thomas, G.A., H.D. Farquar, S. Sutton, R.P. Hammer, and S.A. Soper, Biomems using electrophoresis for the analysis of genetic mutations. Expert Review of Molecular Diagnostics, 2002. 2(5): p. 429-447.

Stryjewski, W.J., S.A. Soper, S. Lassiter, and L.M. Davis, Multiplexed analysis using time-resolved near-ir fluorescence for the detection of genomic material. Proceedings of SPIE-The International Society for Optical Engineering, 2002. 4626(Biomedical Nanotechnology Architectures and Applications): p. 201-209.

Soper, S.A., A.C. Henry, B. Vaidya, M. Galloway, M. Wabuyele, and R.L. McCarley, Surface modification of polymer-based microfluidic devices. Analytica Chimica Acta, 2002. 470(1): p. 87-99.

Qi, S., X. Liu, S. Ford, J. Barrows, G. Thomas, K. Kelly, A. McCandless, K. Lian, J. Goettert, and S.A. Soper, Microfluidic devices fabricated in poly(methyl methacrylate) using hot-embossing with integrated sampling capillary and fiber optics for fluorescence detection. Lab on a Chip, 2002. 2(2): p. 88-95.

Lassiter Suzzane, J., W. Stryjewski, V. Owens Clyde, H. Flanagan James, Jr., P. Hammer Robert, S. Khan, and A. Soper Steven, Optimization of sequencing conditions using near-infrared lifetime identification methods in capillary gel electrophoresis. Electrophoresis FIELD Full Journal Title:Electrophoresis, 2002. 23(10): p. 1480-9.

Lassiter, S.J., W.J. Stryjewski, Y. Wang, and S.A. Soper, Shedding light on DNA analysis multiplexed detection and identification using fluorescence lifetime methods. Spectroscopy (Duluth, MN, United States), 2002. 17(6): p. 14-18,20-23.

Lassiter, S.J., W. Stryjewski, C.V. Owens, J.H. Flanagan, Jr., R.P. Hammer, S. Khan, and S.A. Soper, Optimization of sequencing conditions using near-infrared lifetime identification methods in capillary gel electrophoresis. Electrophoresis, 2002. 23(10): p. 1480-1489.

Hammer, R.P., C.V. Owens, S.-H. Hwang, C.M. Sayes, and S.A. Soper, Asymmetrical, water-soluble phthalocyanine dyes for covalent labeling of oligonucleotides. Bioconjugate Chemistry, 2002. 13(6): p. 1244-1252.

Galloway, M., W. Stryjewski, A. Henry, S.M. Ford, S. Llopis, R.L. McCarley, and S.A. Soper, Contact conductivity detection in poly(methyl methacrylate)-based microfluidic devices for analysis of mono- and polyanionic molecules. Analytical Chemistry, 2002. 74(10): p. 2407-2415.

Galloway, M. and S.A. Soper, Contact conductivity detection of polymerase chain reaction products analyzed by reverse-phase ion pair microcapillary electrochromatography. Electrophoresis, 2002. 23(21): p. 3760-3768.